Aim: The aim of this research work is to determine the presence of hyperthyroidism using modern algorithms, and comparing the accuracy rate between deep learning algorithms and vivo monitoring. Materials and methods: Data collection containing ultrasound images from kaggle's website was used in this research. Samples were considered as (N=23) for Deep learning algorithm and (N=23) for vivo monitoring in accordance to total sample size calculated using clinical.com. The accuracy was calculated by using DPLA with a standard data set.