Artemisia plants have traditional and ethnopharmacological uses in medicine, as well as in culinary items, seasonings, and drinks. Traditional medicine has used this genus as an anti-inflammatory, anti-cancer, anti-malarial, antioxidant, and anti-viral agent. All continents, except Antarctica, have seen its extensive spread. With this study, we want to compile all the available scientific information on the Artemisia genus, including its medicinal properties, chemical make-up, and distribution patterns. Using resources like Web of Science, Scopus, and PubMed/MEDLINE, we culled information from articles written on Artemisia plants. Information on phytochemicals and molecular pathways from preclinical pharmacological experiments was among the articles chosen for this revised review. Also, we looked at several old books and manuscripts. Artemisinin is a sesquiterpene lactone that can kill malaria parasites. Studies have also demonstrated the strong biological effects of other phytochemicals and essential oils from the Artemisia species. Artemisia absinthium L, one of the most well-known species of Artemisia, is the source of absinthe, a banned drink in most countries due to its neurotoxic effects. Research has shown that artemisia plants have several medicinal and traditional uses. Clinical and toxicological studies are the only ones that have provided any solid scientific evidence. As a result, these areas require further investigation in order to fully understand the molecular pharmacological process and therapeutic potential of this medicinal species