Peptide-based drug delivery systems (DDS) have garnered significant attention due to their ability to enhance the targeting, stability, and controlled release of therapeutic agents. This study focuses on the design, synthesis, and in vitro evaluation of peptide-based DDS, aiming to improve the efficacy of drug therapies while minimizing systemic side effects. Peptides are chosen for their biocompatibility, selectivity, and ability to bind specifically to cellular receptors, making them ideal candidates for targeted drug delivery. In this work, a series of peptide conjugates were synthesized by coupling therapeutic drugs with targeting peptides, ensuring optimal drug release profiles.