The aim of this study was to design, formulate, and optimize a floating drug delivery system (FDDS) for chlorthiazide, a thiazide diuretic, to achieve controlled release and prolonged therapeutic effects. The objective was to improve the bioavailability of chlorthiazide by prolonging its gastric retention time using a floating tablet formulation. Floating tablets were prepared using various polymers, including hydroxypropyl methylcellulose (HPMC), sodium bicarbonate, and gellan gum, which were selected based on their ability to form a buoyant system and control drug release. The tablets were characterized for their physical properties, including hardness, friability, weight variation, and in vitro buoyancy.